RESEARCH OVERVIEW

With the advent of designer materials for various biological applications, there is a growing demand for developing new molecular engineering approaches to achieve unmet material functionalities or properties—matching the increasing complexity of our current biomedical challenges. Contributing to this emerging scientific endeavor, our research team will implement a bioinspired retrosynthetic approach for engineering organic materials and their corresponding assemblies to develop appropriate tools and platforms for investigating these biological phenomena at multiple spatial and temporal scales. We will be developing macromolecular and polymeric materials that are optically and electronically active, specifically for the following applications:

  • Materials for Directing and Modulating Cellular Behavior

  • Materials for In Situ Probing of Electromechanical Biological Processes

  • Tissue Engineering Towards Modeling Disease Mechanisms and Toxicological Pathways

​CURRENT SUPPORT:

  • NIH R56: R56HL164348-01, Optically Promoting Cardiac Maturation Using Engineered Peptides    

  • NSF CBET (M. Watanabe, PI; H.A.M. Ardoña, co-PI): #2225624, RECODE:Spatial Engineering of Morphogens for the Reproducible Formation of Cortical Organoids with Arealization

  • University of California, Irvine

PREVIOUS SUPPORT:

  • UCI MRSEC Seed Grant Program, Directed Self-Assembly of Optoelectronic Peptides on Nanostructured Polymeric Surfaces (06/2021– 05/2022)